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Title: Antibacterial, antifungal, and antimycobacterial activity of Ilex aquifolium leaves
Authors: Nurgün Erdemoglu
Gökalp Iscan
Bilge Sener
Prasit Palittapongarnpim
Gazi Universitesi
Anadolu Universitesi
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Aug-2009
Citation: Pharmaceutical Biology. Vol.47, No.8 (2009), 697-700
Abstract: The objective of this study was to examine antibacterial, antifungal, and antimycobacterial properties of Ilex aquifolium L. (Aquifoliaceae) growing in Turkey. The ethanol, ethyl acetate, chloroform, and n-hexane extracts prepared from the leaves of I. aquifolium were tested against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Enterobacter aerogenes, Proteus vulgaris, Salmonella typhimurium, and Candida albicans for antibacterial and antifungal evaluation using the microdilution broth susceptibility assay. In addition, antimycobacterial activity of the crude extracts of I. aquifolium was evaluated by microplate Alamar blue assay. The results showed that the extracts tested, except n-hexane, possessed moderate antibacterial and antifungal activity varying from 62.5 to 250μg/mL. On the other hand, the ethanol extract of the leaves exhibited a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H37Ra strain of 200 μg/mL. © 2009 Informa UK Ltd.
ISSN: 17445116
Appears in Collections:Scopus 2006-2010

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