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Title: Pharmaco/ferrokinetic-related pro-oxidant activity of deferiprone in β-thalassemia
Authors: Totsapol Jirasomprasert
Noppawan Phumala Morales
Lie M G Limenta
Srisuporn Sirijaroonwong
Paveena Yamanont
Prapin Wilairat
Suthat Fucharoen
Udom Chantharaksri
Mahidol University
National University of Singapore
The Institute of Science and Technology for Research and Development, Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 20-Jul-2009
Citation: Free Radical Research. Vol.43, No.5 (2009), 485-491
Abstract: The potential of free radical formation in serum of β-thalassemia/ Hb E patients receiving a single oral dose of 25 mg/kg body weight of deferiprone, a bidentate orally active iron chelator, was evaluated using EPR/spin trapping technique. In the presence of ascorbic acid and tert-butylhydroperoxide, EPR signals of ascorbyl radical (aH= 0.18 mT) and DMPO-carbon centred adduct (aH= 2.37 mT, aN= 1.65 mT) were detected. Shortly after deferiprone administration, EPR signal intensities decreased concomitant with an increase in serum levels of deferiprone. Unfortunately, enhanced EPR signal intensities were observed at 300 min after dosing in patients with serum molar ratio of deferiprone to iron less than 3, suggesting the formation of incomplete iron-deferiprone complexes and consequently free radical formation. To avoid adverse effects of deferiprone, a dosage regimen should be designed according to iron status of the patients and aimed at maintaining an adequate ratio of serum chelator-to-iron concentration.
ISSN: 10292470
Appears in Collections:Scopus 2006-2010

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