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Title: Molecular characterization of Pegarn: A Drosophila homolog of UNC-51 kinase
Authors: A. Ahantarig
L. V. Chadwell
I. B. Terrazas
C. T. Garcia
J. J. Nazarian
H. K. Lee
M. J. Lundell
J. A. Cassill
University of Texas at San Antonio
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jul-2009
Citation: Molecular Biology Reports. Vol.36, No.6 (2009), 1311-1321
Abstract: We have isolated and characterized the gene encoding a Drosophila melanogaster homolog of Caenorhabditis elegans UNC-51 (uncoordinated movement-51): Pegarn. Developmental Northern blot shows the Pegarn gene is expressed at all stages of development. The protein is detected throughout the Drosophila third instar larval central nervous system (CNS) in axons projecting out from the ventral ganglion and in the optic anlagen of the optic lobe. Heterozygous Pegarn mutant embryos show defects in larval axonal neuronal patterning, but survive to adulthood. Homozygous mutants have an even more deformed pattern of neuronal development and do not survive through the larval stages. The data from this research suggest the critical roles of Pegarn in CNS and PNS axonal formation in Drosophila melanogaster and indicates its similar role in other multicellular species. © 2008 Springer Science+Business Media B.V.
ISSN: 15734978
Appears in Collections:Scopus 2006-2010

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