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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/27191
Title: Analysis of differential proteomes in pathogenic and non-pathogenic Leptospira: Potential pathogenic and virulence factors
Authors: Visith Thongboonkerd
Wararat Chiangjong
Putita Saetun
Supachok Sinchaikul
Shui Tein Chen
Uraiwan Kositanont
Mahidol University
Genomics Research Center, Academia Sinica
National Taiwan University
Faculty of Medicine, Siriraj Hospital, Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jul-2009
Citation: Proteomics. Vol.9, No.13 (2009), 3522-3534
Abstract: Leptospirosis is a bacterial zoonotic disease caused by spirochetes in the genus Leptospira. To date, factors determining the pathogenicity and virulence of leptospires remain unclear. We performed a gel-based proteomic analysis to evaluate differential leptospiral proteomes in the pathogenic L. interrogans (serovars Australis, Bratislava, Autumnalis, and Icterohaemorrhagiae) and the non-pathogenic L. biflexa (serovar Patoc). Quantitative proteome analysis and MS protein identification revealed 42 forms of 33 unique proteins whose levels were significantly greater in the pathogenic serovars compared with the non-pathogenic serovar. Among the four pathogenic serovars, the more virulent serovar Icterohaemorrhagiae (which is most commonly associated with severe leptospirosis in patients) had significantly greater levels of 14 forms of 12 unique proteins, when compared with the other three pathogenic serovars. Some of these identified proteins may serve as the pathogenic and/or virulence factors of leptospirosis. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67651238379&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/27191
ISSN: 16159861
16159853
Appears in Collections:Scopus 2006-2010

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