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Title: Cytotoxic properties of root extract and fruit juice of Trichosanthes cucumerina
Authors: Sumonthip Kongtun
Weena Jiratchariyakul
Tanawan Kummalue
Peerapan Tan-ariya
Somyos Kunnachak
August Wilhelm Frahm
Mahidol University
Universitat Freiburg im Breisgau
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jun-2009
Citation: Planta Medica. Vol.75, No.8 (2009), 839-842
Abstract: The root extract of Trichosanthes cucumerina L. and bryonolic acid (1), its main constituent, as well as the fruit juice and cucurbitacin B (3), its main constituent, were tested for cytotoxicity against four human breast cancer cell lines (SKBR3, MCF7, T47D, and MDA-MB435), two lung cancer cell lines (A549 and SK-LU1), and one colon cancer cell line (Caco-2). The root extract had higher IC50 values than bryonolic acid (1) against three breast cancer cell lines (MCF7 = 267/121, T47D = 316/124, MDA-MB435 = 140/90 μL/mL) and one lung cancer cell line (A549 = 106/100 μL/mL). The fruit juice also had higher IC50 values than cucurbitacin B (3) against the four breast cancer cell lines (131/73, 375/35, 249/60, and 156/26 μL/mL, respectively) and one lung cancer cell line (141/41 μL/mL) as shown above, as well as against the colon cancer cell line (101/1.5 μL/mL). However, the root extract inhibited SK-LU1 more strongly than did the fruit juice, cucurbitacin B (3), and bryonolic acid (1) (149/169/180/>500 μL/mL, respectively). The root extract inhibited the two lung and three breast cancer cell lines (SKBR3, MDA-MB435, and MCF7) more strongly than the fruit juice. Bryonolic acid (1) inhibited MDA-MB435 somewhat better than the other tested human cancer cell lines. The fruit juice inhibited the colon cancer cell line (Caco-2) more strongly than the root extract. Cucurbitacin (3) inhibited human cancer cell lines, especially Caco-2, much more strongly than bryonolic acid (1). In addition to bryonolic acid (1), bryononic acid (2), cucurbitacin B (3), and dihydrocucurbitacin B (4) alsowere isolated from the root extract. © Georg Thieme Verlag KG Stuttgart.
ISSN: 14390221
Appears in Collections:Scopus 2006-2010

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