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Title: Aigialomycins and related polyketide metabolites from the mangrove fungus Aigialus parvus BCC 5311
Authors: Masahiko Isaka
Arunrat Yangchum
Sutichai Intamas
Kanokarn Kocharin
E. B.Gareth Jones
Palangpon Kongsaeree
Samran Prabpai
Thailand National Center for Genetic Engineering and Biotechnology
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 30-May-2009
Citation: Tetrahedron. Vol.65, No.22 (2009), 4396-4403
Abstract: Reinvestigation of the secondary metabolites from the marine mangrove fungus Aigialus parvus BCC 5311 led to the isolation of six new nonaketide metabolites, aigialomycins F (4) and G (5a/5b), 7′,8′-dihydroaigialospirol (7), 4′-deoxy-7′,8′-dihydroaigialospirol (8), and rearranged macrolides 9 and 10, along with six previously described compounds, hypothemycin (1), aigialomycins A (2) and B (3), aigialospirol (6), 4-O-demethylhypothemycin (11), and aigialone (12). The structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data in combination with chemical means. © 2009 Elsevier Ltd. All rights reserved.
ISSN: 00404020
Appears in Collections:Scopus 2006-2010

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