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|Title:||Linking dengue virus entry and translation/replication through amphisomes|
Duncan R. Smith
|Keywords:||Biochemistry, Genetics and Molecular Biology|
|Citation:||Autophagy. Vol.5, No.3 (2009), 434-435|
|Abstract:||Amphisomes are preautolysosomal vacuoles formed upon the fusion of autophagosomes with endosomes, and as such represent a critical meeting point between endocytic and autophagic pathways. Dengue virus enters into susceptible cells by clathrin-mediated endocytosis, and colocalization of dengue markers with markers of both autophagic and endosomal vesicles demonstrates that amphi-somes are a site of dengue virus replication and translation. This work links for the first time the processes of dengue virus entry and translation/replication, and allows for interpretation of the early part of the dengue virus life cycle in terms of a continual association with membranes of an endosomal-autophagosomal lineage. © 2009 Landes Bioscience.|
|Appears in Collections:||Scopus 2006-2010|
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