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Title: Bioactive azafluorenone alkaloids from Polyalthia debilis (pierre) finet & Gagnep.
Authors: Supaluk Prachayasittikul
Patumporn Manam
Maneekarn Chinworrungsee
Chartchalerm Isarankura-Na-ayudhya
Somsak Ruchirawat
Virapong Prachayasittikul
Srinakharinwirot University
Mahidol University
Chulabhorn Research Institute
Keywords: Chemistry
Issue Date: 1-Nov-2009
Citation: Molecules. Vol.14, No.11 (2009), 4414-4424
Abstract: This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of β-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 μg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.
ISSN: 14203049
Appears in Collections:Scopus 2006-2010

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