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Title: Copper complexes of pyridine derivatives with superoxide scavenging and antimicrobial activities
Authors: Thummaruk Suksrichavalit
Supaluk Prachayasittikul
Chanin Nantasenamat
Chartchalerm Isarankura-Na-Ayudhya
Virapong Prachayasittikul
Mahidol University
Srinakharinwirot University
Keywords: Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Aug-2009
Citation: European Journal of Medicinal Chemistry. Vol.44, No.8 (2009), 3259-3265
Abstract: Superoxide anions are reactive oxygen species that can attack biomolecules such as DNA, lipids and proteins to cause many serious diseases. This study reports the synthesis of copper complexes of nicotinic acid with related pyridine derivatives. The copper complexes were shown to possess superoxide dismutase (SOD) and antimicrobial activities. The copper complexes exerted SOD activity in range of 49.07-130.23 μM. Particularly, copper complex of nicotinic acid with 2-hydroxypyridine was the most potent SOD mimic with an IC50of 49.07 μM. In addition, the complexes exhibited antimicrobial activity against Bacillus subtilis ATCC 6633 and Candida albicans ATCC 90028 with MIC range of 128-256 μg/mL. The SOD activities were well correlated with the theoretical parameters as calculated by density functional theory at the B3LYP/LANL2DZ level of theory. Interestingly, the SOD activity of the copper complexes was demonstrated to be inversely correlated with the electron affinity, but was well correlated with both HOMO and LUMO energies. The vitamin-metal complexes described in this report are great examples of the value-added benefits of vitamins for medicinal applications. © 2009 Elsevier Masson SAS. All rights reserved.
ISSN: 17683254
Appears in Collections:Scopus 2006-2010

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