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dc.contributor.authorPhetsavanh Chanthavilayen_US
dc.contributor.authorReinharz, Danielen_US
dc.contributor.authorMayfong Mayxayen_US
dc.contributor.authorKeokedthong Phongsavanen_US
dc.contributor.authorMarsden, Donald E.en_US
dc.contributor.authorMoore, Lynneen_US
dc.contributor.authorWhite, Lisa J.en_US
dc.contributor.otherMahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Uniten_US
dc.date.accessioned2017-08-09T05:21:30Z-
dc.date.available2017-08-09T05:21:30Z-
dc.date.created2017-08-09-
dc.date.issued2016-
dc.identifier.citationBMC Health Services Research. Vol. 16, (2016), 418en_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/2747-
dc.description.abstractBackground: Cervical cancer, a preventable disease, is the third leading cause of cancer morbidity and mortality in the Lao People’s Democratic Republic (Lao PDR). Since many cervical cancers are linked to human papilloma virus (HPV) infection, vaccination against this virus may lead to a reduction in these types of cancer. The study described here is the first to compare the cost-effectiveness of different HPV vaccination options in Lao PDR. Methods: A dynamic compartment model was created. The model included routine screening activities already in place, as well as theoretical interventions that included a 10-year old girl-only vaccination programme combined with/without a 10-year old boy vaccination programme and/or a catch-up component. The simulation was run over 100 years. In base case analyses, we assumed 70 % vaccination coverage with lifelong protection and 100 % efficacy against HPV types 16/18. The outcomes of interest were the incremental cost per Disability-Adjusted Life Year (DALY) averted. Results: In base case analyses, according to the WHO definition of cost-effectiveness thresholds, vaccinating 10-year-old girls was very cost-effective. Adding a catch-up vaccination element for females aged 11–25 years was also very cost-effective, costing 1559 international dollars (I$) per DALY averted. Increasing the age limit of the catch-up vaccination component to 75 years old showed that this remained a cost-effective option (I$ 5840 per DALY averted). Adding a vaccination programme for 10-year-old boys was not found to be cost-effective unless a short time simulation (30 years or less) was considered, along with a catch-up vaccination component for both males and females. Conclusions: Adding a catch-up female vaccination component is more attractive than adding a 10-year-old boy vaccination component.en_US
dc.language.isoenen_US
dc.rightsMahidol Universityen_US
dc.subjectOpen Access articleen_US
dc.subjectEconomic evaluationen_US
dc.subjectHPV vaccinationen_US
dc.subjectCervical canceren_US
dc.subjectLao PDRen_US
dc.titleThe economic evaluation of human papillomavirus vaccination strategies against cervical cancer in women in Lao PDR: a mathematical modelling approachen_US
dc.typeResearch Articleen_US
dc.rights.holderBioMed Centralen_US
dc.identifier.doi10.1186/s12913-016-1662-5-
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