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Title: Serum antibodies and cytokines in C4-deficient mice and their responses to exercise
Authors: Supawan Visetnoi
Runglawan Chawengkirttikul
Sansanee C. Chaiyaroj
Yindee Kitiyanant
Chumpol Pholpramool
Department of Physiology
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Dec-2009
Citation: Asian Pacific Journal of Allergy and Immunology. Vol.27, No.4 (2009), 199-206
Abstract: Psychological stress is believed to be one of the predisposing factors for systemic lupus erythemato-sus (SLE), whereas physical stress such as exercise has never been reported to be related. We measured the cir-culating levels of antibodies (IgM, IgG, anti-dsDNA IgG), Th1 (IFN-γ), Th2 (IL-4, IL-6), and of pro-inflammatory (TNF-α, IL-1β) and anti-inflammatory (TGF-β) cytokines of C4-/- female mice at rest, after acute exercise and after exercise training, using an antibody-capture ELISA. Prior to the exercise, the C4-/- mice had higher levels of IgG and anti-dsDNA IgG but lower levels of IFN-γ, IL-1β, IL-6 and IL-4 than wild-type C57BL/6 (B6) mice. A single bout of exercise to exhaustion increased serum IgG, TNF-α, IL-1β and TGF-β in the B6 mice but only TGF-β in the C4-/- mice was increased. We conclude that exhaustive or moderate exercise has no effect on the levels of serum anti-bodies and cytokines and is thus unlikely to promote the onset of SLE.
ISSN: 0125877X
Appears in Collections:Scopus 2006-2010

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