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Title: Molecular basis of human cerebral malaria development
Authors: Saw Thu Wah
Hathairad Hananantachai
Usanee Kerdpin
Chotiros Plabplueng
Virapong Prachayasittikul
Pornlada Nuchnoi
Mahidol University. Faculty of Medical Technology. Department of Clinical Microscopy
Mahidol University. Faculty of Medical Technology. Center for Research and Innovation
Keywords: Cerebral malaria;Genetics;Pathogenesis;MicroRNA;Open Access article
Issue Date: 2016
Citation: Tropical Medicine and Health. Vol.44, (2016), 33
Abstract: Cerebral malaria is still a deleterious health problem in tropical countries. The wide spread of malarial drug resistance and the lack of an effective vaccine are obstacles for disease management and prevention. Parasite and human genetic factors play important roles in malaria susceptibility and disease severity. The malaria parasite exerted a potent selective signature on the human genome, which is apparent in the genetic polymorphism landscape of genes related to pathogenesis. Currently, much genomic data and a novel body of knowledge, including the identification of microRNAs, are being increasingly accumulated for the development of laboratory testing cassettes for cerebral malaria prevention. Therefore, understanding of the underlying complex molecular basis of cerebral malaria is important for the design of strategy for cerebral malaria treatment and control.
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