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Title: Immediate type hypersensitivity to chemotherapeutic agents in pediatric patients
Authors: Nualanong Visitsunthorn
Wipa Utsawapreechawong
Punchama Pacharn
Orathai Jirapongsananuruk
Pakit Vichyanond
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Dec-2009
Citation: Asian Pacific Journal of Allergy and Immunology. Vol.27, No.4 (2009), 191-197
Abstract: Nine patients (3 boys and 6 girls) with a median age of 9.5 years, with immediate type hypersensitivity reactions to chemotherapeutic agents were reviewed. The presenting symptoms were urticaria (4/9) and anaphylaxis (5/9). The causative agents were vincristine (2/9), L asparaginase (2/9), mesna (1/9), cyclosporine (1/9), carboplatin (2/9) and cyclophosphamide (1/9). Three of the five patients with anaphylaxis were changed to alternative chemotherapeutic agents. In two cases alternative drugs were not available and the patients underwent safe and successful desensitization. Three of the 4 patients with urticaria were successfully exposed to graded challenges with cyclosporine, carboplatin and cyclophosphamide, respectively. In the other case with generalized urticaria, mesna was withdrawn due to a positive intradermal test. In patients with immediate type hypersensitivity reactions to chemotherapeutic drugs, if effective alternative chemotherapeutic agents are not available and/or the skin test is negative, a careful drug challenge and/or desensitization should be performed.
ISSN: 0125877X
Appears in Collections:Scopus 2006-2010

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