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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/27629
Title: Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria
Authors: Izumi Naka
Nao Nishida
Jintana Patarapotikul
Pornlada Nuchnoi
Katsushi Tokunaga
Hathairad Hananantachai
Naoyuki Tsuchiya
Jun Ohashi
University of Tsukuba
University of Tokyo
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 30-Nov-2009
Citation: Malaria Journal. Vol.8, No.1 (2009)
Abstract: Background. It has been previously demonstrated that a single nucleotide polymorphism (SNP) in the IL13 promoter region, IL13 -1055T>C (rs1800925), was associated with susceptibility to severe malaria in Thais. In the present study, fine association mapping for a cytokine gene cluster including IL4, IL5, and IL13 on chromosome 5q31 was conducted using the same malaria subjects to refine the region containing a primary variant or a haplotype susceptible to severe malaria. Methods. A total of 82 SNPs spanning 522 kb of the 5q31 region were analysed in 368 patients with Plasmodium falciparum malaria (203 mild malaria and 165 severe malaria patients). Results. Only rs1881457 located in the promoter region of IL13, which is in linkage disequilibrium with rs1800925 (r2 = 0.73), showed a significant association with severe malaria after adjusting for multiple testing (P = 0.046 by permutation test). This SNP was in a haplotype block spanning 97 kb (from rs2069812 to rs2240032). The detected haplotype block contained the RAD50 gene and the promoter of IL13, but not the other genes. Conclusion. A haplotype block in which a primary polymorphism associated with severe malaria is likely to be encoded was identified in Thai malaria patients.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70450265563&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/27629
ISSN: 14752875
Appears in Collections:Scopus 2006-2010

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