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Title: Schistosoma mansoni infection of juvenile Biomphalaria glabrata induces a differential stress response between resistant and susceptible snails
Authors: Wannaporn Ittiprasert
Rahul Nene
André Miller
Nithya Raghavan
Fred Lewis
Jacob Hodgson
Matty Knight
Biomedical Research Institute, Rockville
Mahidol University
The University of British Columbia
Keywords: Immunology and Microbiology
Issue Date: 1-Nov-2009
Citation: Experimental Parasitology. Vol.123, No.3 (2009), 203-211
Abstract: Schistosomes develop successfully in susceptible snails but are encapsulated and killed in resistant ones. Mechanism(s) shaping these outcomes involves the parasites ability to evade the snail's defenses. RNA analysis from resistant (BS-90), non-susceptible (LAC2) and susceptible (NMRI) juvenile Biomphalaria glabrata to Schistosoma mansoni revealed that stress-related genes, heat shock protein 70 (Hsp 70) and reverse transcriptase (RT), were dramatically co-induced early in susceptible snails, but not in resistant/non-susceptible ones. These transcripts were, however, down regulated upon exposure to irradiated parasites although penetration behavior of irradiated vs. normal parasites were the same, indicating that Hsp 70 and RT regulation was elicited by infection and not injury. Understanding molecular events involved in stress response transcriptional regulation of Hsp 70 in juvenile snails could pave a way towards the identification of genes involved in schistosome/snail interactions. © 2009 Elsevier Inc. All rights reserved.
ISSN: 10902449
Appears in Collections:Scopus 2006-2010

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