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Title: Cerebral malaria: A new way forward with magnetic resonance imaging (MRI)
Authors: Sornchai Looareesuwan
Jiraporn Laothamatas
Truman R. Brown
Gary M. Brittenham
Mahidol University
Columbia University, College of Physicians and Surgeons
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Oct-2009
Citation: American Journal of Tropical Medicine and Hygiene. Vol.81, No.4 (2009), 545-547
Abstract: Magnetic resonance studies offer a new way through the impasse that now seems to block further progress in disentangling the pathogenesis and improving the treatment of cerebral malaria, a catastrophic neurologic complication of infection with Plasmodium falciparum. The underlying mechanisms responsible for coma in cerebral malaria are still unknown and the relative contributions of the microvascular sequestration of infected erythrocytes, the inflammatory response to P. falciparum, disordered hemostasis, and other factors remain controversial. For more than a century, neuropathologic studies have provided the basis for concepts of causation of cerebral malaria. Magnetic resonance techniques now offer non-invasive means of determining essential anatomic, metabolic, biochemical, and functional features of the brain in patients with cerebral malaria during life that could transform our understanding of the pathogenesis of cerebral malaria and lead to the development of new neuroprotective treatments. Copyright © 2009 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2006-2010

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