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Title: The impact of combination antiretroviral therapy and its interruption on anxiety, stress, depression and quality of life in thai patients
Authors: Reto Nüesch
Angèle Gayet-Ageron
Ploenchan Chetchotisakd
Wisit Prasithsirikul
Sasisopin Kiertiburanakul
Warangkana Munsakul
Phitsanu Raksakulkarn
Somboon Tansuphasawasdikul
Sineenart Chautrakarn
Kiat Ruxrungtham
Bernard Hirschel
Jintanat Anaworanich
Praphan Phanuphak
Sukontha Saenawat
Saijai Wicharuk
Siriporn Nonenoy
Natnipa Wannachai
Theshinee Chuenyam
Thanthip Nuchapong
Apicha Mahanontharit
Jongkol Sankonte
Bucha Piyavong
Vantanit Piroj
Napawan Seekaow
Wipawan Karakte
Sasiwimol Ubolyam
Suchittra Putthwong
Sirirat Liganonsakul
Wattana Sanchiem
Pongpan Boonchoo
Malee Suannum
Parichat Bunyaprawit
Ratthanant Kaewmarg
Yaowaluk Penglimoon
Sopha Khongsawad
The HIV Netherlands Australia Thailand Research Collaboration
Universitatsspital Basel
Hopitaux universitaires de Geneve
Khon Kaen University
Bamrasnaradura Infectious Disease Institute
Mahidol University
Vajira Hospital
Sanpatong Hospital
Buddhachinnaraj Hospital
Keywords: Immunology and Microbiology;Medicine
Issue Date: 25-Sep-2009
Citation: Open AIDS Journal. Vol.3, (2009), 38-45
Abstract: Objective: Investigation on anxiety, stress, depression, and quality of life (QoL) within STACCATO, a randomised trial of two treatment strategies: CD4 guided scheduled treatment interruption (STI) compared to continuous treatment (CT). Participants: Thai patients with HIV-infection enrolled in the STACCATO trial. Methods: Anxiety, depression assessed by the questionnaires Hospital Anxiety and Depression Scale (HADS) and DASS, stress assessed by the Depression Anxiety Stress Scale (DASS), and QoL evaluated by the HIV Medical Outcome Study (MOS-HIV) questionnaires. Answers to questionnaires were evaluated at 4 time-points: baseline, 24 weeks, 48 weeks and at the end of STACCATO. Results: A total of 251 patients answered the HADS/DASS and 241 answered the MOS-HIV of the 379 Thai patients enrolled into STACCATO (66.2 and 63.6% respectively). At baseline 16.3% and 7.2% of patients reported anxiety and depression using HADS scale. Using the DASS scale, 35.1% reported mild to moderate and 9.6% reported severe anxiety; 8.8% reported mild to moderate and 2.0% reported severe depression; 42.6% reported mild to moderate and 4.8% reported severe stress. We showed a significant improvement of the MHS across time (p=0.001), but no difference between arms (p=0.17). The summarized physical health status score (PHS) did not change during the trial (p=0.15) nor between arm (p=0.45). There was no change of MHS or PHS in the STI arm, taking into account the number of STI cycle (p=0.30 and 0.57) but MHS significant increased across time-points (p=0.007). Conclusion: Antiretroviral therapy improved mental health and QOL, irrespective of the treatment strategy. © Nüesch et al.
ISSN: 18746136
Appears in Collections:Scopus 2006-2010

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