Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: Spatial distribution and risk factors of dengue and Japanese encephalitis virus infection in urban settings: The case of Vientiane, Lao PDR
Authors: Julie Vallée
Audrey Dubot-Pérès
Phonepaseuth Ounaphom
Chantalay Sayavong
Juliet E. Bryant
Jean Paul Gonzalez
Institut de Recherche pour le Développement
Universite Paris Nanterre
Sorbonne Universite
Faculte de Medecine de Marseille Universite de la Mediterranee
Mahidol University
Department of Public Health
Institut Pasteur, Paris
Centre International de Recherches Medicales de Franceville
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Sep-2009
Citation: Tropical Medicine and International Health. Vol.14, No.9 (2009), 1134-1142
Abstract: Objectives To evaluate the prevalence of flavivirus infection in Vientiane city (Lao PDR), to describe the spatial distribution of infection within this city, and to explore the link between flavivirus seroprevalence and urbanization levels of residential neighbourhoods. Methods A seroprevalence survey was carried out in 2006 including 1990 adults (≥35 years) and 1568 children (≥6months and <6 years) randomly selected. Results The prevalence of individuals with previous flavivirus infection (i.e. negative for both DEN and JE IgM but positive for DEN IgG) was 57.7%, with a significantly (P < 0.001) higher prevalence among adults (84.6%; 95% confidence interval (CI) = 82.4-86.8) than children (9.4%; 95% CI = 7.2-11.6). The prevalence of individuals with recent flavivirus infection (i.e. positive for DEN and\or JE IgM) was 6.5% and also significantly (P < 0.001) higher among adults (10.0%; 95% CI = 8.3-11.7) than children (2.5%; 95% CI = 1.5-3.5). In terms of spatial distribution, IgG prevalence was significantly (P < 0.001) higher among individuals living in the central city (60.1%; 95% CI = 56.2-64.1) than among those living in the periphery (44.3%; 95% CI = 41.5-47.2). In contrast, seroprevalence of recent flavivirus infections was significantly (P < 0.001) higher among individuals living in the periphery (8.8%; 95% CI = 6.9-10.7) than in the central city (4.0%; 95% CI = 2.9-5.2). This association was also statistically consistant (P < 0.01) in multivariate logistic regression after controlling for individual risk factors. Conclusions Our findings indicate that the level of urbanization of residential neighbourhoods influences the risk of flavivirus infection. The spatial distribution of flavivirus infection varies, even within a small city of less than 300 000 habitants such as Vientiane. © 2009 Blackwell Publishing Ltd.
ISSN: 13653156
Appears in Collections:Scopus 2006-2010

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.