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dc.contributor.authorJulie Valléeen_US
dc.contributor.authorAudrey Dubot-Pérèsen_US
dc.contributor.authorPhonepaseuth Ounaphomen_US
dc.contributor.authorChantalay Sayavongen_US
dc.contributor.authorJuliet E. Bryanten_US
dc.contributor.authorJean Paul Gonzalezen_US
dc.contributor.otherInstitut de Recherche pour le Développementen_US
dc.contributor.otherUniversite Paris Nanterreen_US
dc.contributor.otherSorbonne Universiteen_US
dc.contributor.otherFaculte de Medecine de Marseille Universite de la Mediterraneeen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherDepartment of Public Healthen_US
dc.contributor.otherInstitut Pasteur, Parisen_US
dc.contributor.otherCentre International de Recherches Medicales de Francevilleen_US
dc.identifier.citationTropical Medicine and International Health. Vol.14, No.9 (2009), 1134-1142en_US
dc.description.abstractObjectives To evaluate the prevalence of flavivirus infection in Vientiane city (Lao PDR), to describe the spatial distribution of infection within this city, and to explore the link between flavivirus seroprevalence and urbanization levels of residential neighbourhoods. Methods A seroprevalence survey was carried out in 2006 including 1990 adults (≥35 years) and 1568 children (≥6months and <6 years) randomly selected. Results The prevalence of individuals with previous flavivirus infection (i.e. negative for both DEN and JE IgM but positive for DEN IgG) was 57.7%, with a significantly (P < 0.001) higher prevalence among adults (84.6%; 95% confidence interval (CI) = 82.4-86.8) than children (9.4%; 95% CI = 7.2-11.6). The prevalence of individuals with recent flavivirus infection (i.e. positive for DEN and\or JE IgM) was 6.5% and also significantly (P < 0.001) higher among adults (10.0%; 95% CI = 8.3-11.7) than children (2.5%; 95% CI = 1.5-3.5). In terms of spatial distribution, IgG prevalence was significantly (P < 0.001) higher among individuals living in the central city (60.1%; 95% CI = 56.2-64.1) than among those living in the periphery (44.3%; 95% CI = 41.5-47.2). In contrast, seroprevalence of recent flavivirus infections was significantly (P < 0.001) higher among individuals living in the periphery (8.8%; 95% CI = 6.9-10.7) than in the central city (4.0%; 95% CI = 2.9-5.2). This association was also statistically consistant (P < 0.01) in multivariate logistic regression after controlling for individual risk factors. Conclusions Our findings indicate that the level of urbanization of residential neighbourhoods influences the risk of flavivirus infection. The spatial distribution of flavivirus infection varies, even within a small city of less than 300 000 habitants such as Vientiane. © 2009 Blackwell Publishing Ltd.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleSpatial distribution and risk factors of dengue and Japanese encephalitis virus infection in urban settings: The case of Vientiane, Lao PDRen_US
Appears in Collections:Scopus 2006-2010

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