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Title: Atorvastatin attenuates TLR4-mediated NF-κB activation in a MyD88-dependent pathway
Authors: Praveen Chansrichavala
Udom Chantharaksri
Piyamitr Sritara
Sansanee C. Chaiyaroj
Mahidol University
Chulabhorn Research Institute
Keywords: Immunology and Microbiology;Medicine
Issue Date: 3-Aug-2009
Citation: Asian Pacific Journal of Allergy and Immunology. Vol.27, No.1 (2009), 49-57
Abstract: Antigen presenting cells such as dendritic cells and macrophages have recently been detected in atherosclerotic plaques. Toll-like receptors expressed on the surface of these cells, have been implicated in ongoing inflammatory responses in the plaques. In this study, we investigated the anti-inflammatory effect of atorvastatin, a lipid lowering drug, via Toll-like receptor 4 (TLR4) in vitro, employing murine pro-B cell lines transfected with hTLR4/MD2 and MyD88/hTLR4/MD2 systems. The results showed that atorvastatin at 10 μM significantly attenuated NF-κB activation within 24 hours while at lower doses of 0.1 and 1 μM, treatment time had to be prolonged up to 48 hours for a significant inhibition to occur. The inhibition of NF-κB was also observed in a cell line cotransfected with MyD88 and TLR4 suggesting that the attenuation of NF-κB by atorvastatin occurred in a MyD88 dependent fashion.
ISSN: 0125877X
Appears in Collections:Scopus 2006-2010

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