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Title: Sennetsu neorickettsiosis: A probable fish-borne cause of fever rediscovered in Laos
Authors: Paul N. Newton
Jean Marc Rolain
Bouachanh Rasachak
Mayfong Mayxay
Khamtanh Vathanatham
Piseth Seng
Rattanaphone Phetsouvanh
Te Thammavong
Jamaayah Zahidi
Yupin Suputtamongkol
Bounkong Syhavong
Didier Raoult
Mahosot Hospital
Universite de la Mediterranee Aix-Marseille II
Nuffield Department of Clinical Medicine
University of Health Sciences
Living Aquatic Resources Research Centre (LARReC)
Lao Red Cross
Institute for Medical Research Kuala Lumpur
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Aug-2009
Citation: American Journal of Tropical Medicine and Hygiene. Vol.81, No.2 (2009), 190-194
Abstract: Neorickettsia sennetsu has been described from Japan and Malaysia, causing a largely forgotten infectious mononucleosis-like disease. Because it is believed to be contracted from eating raw fish, frequently consumed in the Lao PDR, we looked for evidence of N. sennetsu among Lao patients and fish. A buffy coat from 1 of 91 patients with undifferentiated fever was positive by 16S rRNA amplification and sequencing and real-time polymerase chain reactions (PCR) targeting two N. sennetsu genes. Lao blood donors and patients with fever, hepatitis, or jaundice (N = 1,132) had a high prevalence (17%) of immunofluorescence assay IgG anti-N. sennetsu antibodies compared with 4% and 0% from febrile patients (N = 848) in Thailand and Malaysia, respectively. We found N. sennetsu DNA by PCR, for the first time, in a fish (Anabas testudineus). These data suggest that sennetsu may be an under-recognized cause of fever and are consistent with the hypothesis that it may be contracted from eating raw fish. Copyright © 2009 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2006-2010

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