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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/27695
Title: The spectrum of retinopathy in adults with Plasmodium falciparum malaria
Authors: Richard J. Maude
Nicholas A V Beare
Abdullah Abu Sayeed
Christina C. Chang
Prakaykaew Charunwatthana
M. Abul Faiz
Amir Hossain
Emran Bin Yunus
M. Gofranul Hoque
Mahtab Uddin Hasan
Nicholas J. White
Nicholas P J Day
Arjen M. Dondorp
Mahidol University
John Radcliffe Hospital
Royal Liverpool and Broadgreen University Hospitals NHS Trust
Chittagong Medical College Hospital
Malaria Research Group (MRG)
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jul-2009
Citation: Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.103, No.7 (2009), 665-671
Abstract: A specific retinopathy has been described in African children with cerebral malaria, but in adults this has not been extensively studied. Since the structure and function of the retinal vasculature greatly resembles the cerebral vasculature, study of retinal changes can reveal insights into the pathophysiology of cerebral malaria. A detailed observational study of malarial retinopathy in Bangladeshi adults was performed using high-definition portable retinal photography. Retinopathy was present in 17/27 adults (63%) with severe malaria and 14/20 adults (70%) with cerebral malaria. Moderate or severe retinopathy was more frequent in cerebral malaria (11/20, 55%) than in uncomplicated malaria (3/15, 20%; P = 0.039), bacterial sepsis (0/5, 0%; P = 0.038) or healthy controls (0/18, 0%; P < 0.001). The spectrum of malarial retinopathy was similar to that previously described in African children, but no vessel discolouration was observed. The severity of retinal whitening correlated with admission venous plasma lactate (P = 0.046), suggesting that retinal ischaemia represents systemic ischaemia. In conclusion, retinal changes related to microvascular obstruction were common in adults with severe falciparum malaria and correlated with disease severity and coma, suggesting that a compromised microcirculation has important pathophysiological significance in severe and cerebral malaria. Portable retinal photography has potential as a valuable tool to study malarial retinopathy. © 2009 Royal Society of Tropical Medicine and Hygiene.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67349208894&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/27695
ISSN: 00359203
Appears in Collections:Scopus 2006-2010

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