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Title: Wheat-dependent, exercise-induced anaphylaxis in Thai children: A report of 5 cases
Authors: Punchama Pacharn
Orathai Jirapongsananuruk
Tassalapa Daengsuwan
Pakit Vichyanond
Nualanong Visitsunthorn
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jun-2009
Citation: Asian Pacific Journal of Allergy and Immunology. Vol.27, No.2-3 (2009), 115-120
Abstract: Wheat is not an uncommon cause of food-dependent, exercise-induced anaphylaxis. This study aims to describe common clinical characteristics and laboratory manifestations of the disease. Five children, aged 8-14 years were evaluated. An atopic history was found in 20% of the patients. All patients had symptoms which involved the skin and three had hypotension. Serum specific IgE for wheat was measured and showed a positive result in 2 patients. A three-day challenge protocol with an open challenge for wheat on day 1, an exercise challenge test on day 2 and another exercise challenge test on day 3 after a meal containing wheat was performed. Four patients completed the three-day challenge protocol. Anaphylaxis occurred in 2 out of 4 patients who consumed more than 100 grams of wheat prior to the exercise. The three-day challenge protocol is a definitive diagnostic tool to confirm the diagnosis of WDEIA. However, the amount of wheat used for challenging should be at least 100 grams.
ISSN: 0125877X
Appears in Collections:Scopus 2006-2010

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