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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/27710
Title: High prevalence of hepatitis C virus genotype 6 in Vietnam
Authors: Anh Pham Duc
Pornsawan Leuangwutiwong
Akanitt Jittmittraphap
Nattanej Luplertlop
Khanh Bach Hoa
Srunthron Akkarathamrongsin
Apiradee Theamboonlers
Yong Poovorawan
Thaibinh Medical University
Mahidol University
National Institute of Hematology and Blood Transfusion
Chulalongkorn University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jun-2009
Citation: Asian Pacific Journal of Allergy and Immunology. Vol.27, No.2-3 (2009), 153-160
Abstract: This study aimed to update the prevalence of the various Hepatitis C virus genotypes in Vietnamese blood donors. One hundred and three HCV antibody-positive plasma samples were collected from blood donors at the National Institute of Hematology and Blood Transfusion, Hanoi, Vietnam. All specimens were subjected to RT-PCR of the 5′ untranslated region (UTR) to confirm the presence of HCV RNA. The core and NS5B regions of the positive samples were subsequently amplified by RT-PCR followed by direct sequencing and phylogenetic analysis. Seventy out of 103 samples (68.0%) were RNA positive. Core and NS5B were successfully amplified and sequences were obtained for 70 and 65 samples, respectively. Phylogenetic analysis revealed that genotype 6a was the most predominant among Vietnamese blood donors with a prevalence of 37.1% (26/70), followed by genotype 1a at 30.0% (21/70) and genotype 1b at 17.1% (12/70). The prevalence of two other genotype 6 variants, 6e and 6l was 8.6% and 1.4%, respectively. Further analysis of recent studies showed that the geographic distribution of genotype 6 covered mainly southern China and the mainland of Southeast Asia including Vietnam, Laos, Thailand, and Myanmar. The GenBank accession numbers for the sequences reported in this study are FJ768772-FJ768906.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70350707742&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/27710
ISSN: 0125877X
Appears in Collections:Scopus 2006-2010

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