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Title: Antimalarial drug susceptibility of Plasmodium vivax in the Republic of Korea
Authors: Kesinee Chotivanich
Jetsumon Sattabongkot
Kyong Choi Yien
Sun Park Jae
Juntima Sritabal
Seung Lim Chae
Rachanee Udomsangpetch
Nicholas J. White
Ja Lee Won
Mahidol University
Armed Forces Research Institute of Medical Sciences, Thailand
Korea Centers for Disease Control & Prevention
Korea University
Churchill Hospital
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jun-2009
Citation: American Journal of Tropical Medicine and Hygiene. Vol.80, No.6 (2009), 902-904
Abstract: The antimalarial susceptibility of ring stage (> 80%) Plasmodium vivax from the Republic of Korea, where long incubation-period strains are prevalent, was evaluated using the schizont maturation inhibition technique. During 2005-2007, susceptibility to seven antimalarial drugs was evaluated with 24 fresh isolates. The geometric mean (95% confidence interval) 50% inhibition concentration (IC50) were quinine 60 (54-75) ng/mL, chloroquine 39 (22-282) ng/mL, piperaquine 27 (17-58) ng/mL, mefloquine 39 (35-67) ng/mL, pyrimethamine 138 (89-280) ng/mL, artesunate 0.6 (0.5-0.8) ng/mL, and primaquine 122 (98-232) ng/mL. Positive correlations were found between quinine and mefloquine (r = 0.6, P = 0.004), piperaquine and chloroquine (r = 0.6, P = 0.008), and piperaquine and primaquine IC50values (r = 0.5, P = 0.01). Compared with P. vivax in Thailand, P. vivax in the Republic of Korea was more sensitive to quinine and mefloquine, but equally sensitive to chloroquine and artesunate. Copyright © 2009 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2006-2010

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