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dc.contributor.authorKesinee Chotivanichen_US
dc.contributor.authorJetsumon Sattabongkoten_US
dc.contributor.authorKyong Choi Yienen_US
dc.contributor.authorSun Park Jaeen_US
dc.contributor.authorJuntima Sritabalen_US
dc.contributor.authorSeung Lim Chaeen_US
dc.contributor.authorRachanee Udomsangpetchen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.authorJa Lee Wonen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherArmed Forces Research Institute of Medical Sciences, Thailanden_US
dc.contributor.otherKorea Centers for Disease Control & Preventionen_US
dc.contributor.otherKorea Universityen_US
dc.contributor.otherChurchill Hospitalen_US
dc.identifier.citationAmerican Journal of Tropical Medicine and Hygiene. Vol.80, No.6 (2009), 902-904en_US
dc.description.abstractThe antimalarial susceptibility of ring stage (> 80%) Plasmodium vivax from the Republic of Korea, where long incubation-period strains are prevalent, was evaluated using the schizont maturation inhibition technique. During 2005-2007, susceptibility to seven antimalarial drugs was evaluated with 24 fresh isolates. The geometric mean (95% confidence interval) 50% inhibition concentration (IC50) were quinine 60 (54-75) ng/mL, chloroquine 39 (22-282) ng/mL, piperaquine 27 (17-58) ng/mL, mefloquine 39 (35-67) ng/mL, pyrimethamine 138 (89-280) ng/mL, artesunate 0.6 (0.5-0.8) ng/mL, and primaquine 122 (98-232) ng/mL. Positive correlations were found between quinine and mefloquine (r = 0.6, P = 0.004), piperaquine and chloroquine (r = 0.6, P = 0.008), and piperaquine and primaquine IC50values (r = 0.5, P = 0.01). Compared with P. vivax in Thailand, P. vivax in the Republic of Korea was more sensitive to quinine and mefloquine, but equally sensitive to chloroquine and artesunate. Copyright © 2009 by The American Society of Tropical Medicine and Hygiene.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleAntimalarial drug susceptibility of Plasmodium vivax in the Republic of Koreaen_US
Appears in Collections:Scopus 2006-2010

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