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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/27717
Title: Comparison of indirect immunofluorescence assays for diagnosis of scrub typhus and murine typhus using venous blood and finger prick filter paper blood spots
Authors: Rattanaphone Phetsouvanh
Stuart D. Blacksell
Kemajittra Jenjaroen
Nicholas P.J. Day
Paul N. Newton
Mahosot Hospital
University of Oxford
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-May-2009
Citation: American Journal of Tropical Medicine and Hygiene. Vol.80, No.5 (2009), 837-840
Abstract: We performed indirect immunofluorescence assays (IFAs) to compare levels of IgM and IgG antibodies to Orientia tsutsugamushi and Rickettsia typhi in admission-phase serum samples and filter paper blood spots (assayed immediately and stored at 5.4°C and 29°C for 30 days) collected on the same day from 53 adults with suspected scrub typhus and murine typhus admitted to Mahosot Hospital Vientiane, Lao People's Democratic Republic. The sensitivities and specificities of admission-phase filter paper blood spots in comparison to paired sera were between 91% and 95% and 87% and 100%, respectively, for the diagnosis of scrub typhus and murine typhus. The classification of patients as having or not having typhus did not significantly differ after storage of the blood spots for 30 days (P > 0.4) at 5.4°C and 29°C. Because filter paper blood samples do not require sophisticated and expensive storage and transport, they may be an appropriate specimen collection technique for the diagnosis of rickettsial disease in the rural tropics. Copyright © 2009 by The American Society of Tropical Medicine and Hygiene.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=66149158511&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/27717
ISSN: 00029637
Appears in Collections:Scopus 2006-2010

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