Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorJiraprapa Wipasaen_US
dc.contributor.authorHuji Xuen_US
dc.contributor.authorXueqin Liuen_US
dc.contributor.authorChakrit Hirunpeteharaten_US
dc.contributor.authorAnthony S. Towersen_US
dc.contributor.authorMichael F. Gooden_US
dc.contributor.otherRoyal Brisbane Hospitalen_US
dc.contributor.otherChiang Mai Universityen_US
dc.contributor.otherChangzheng Hospitalen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNational Institute of Allergy and Infectious Diseasesen_US
dc.identifier.citationInfection and Immunity. Vol.77, No.2 (2009), 817-824en_US
dc.description.abstractIt is well known that exposure to one antigen can modulate the immune responses that develop following exposure to closely related antigens. It is also known that the composition of the repertoire can be skewed to favor epitopes shared between a current infection and a preceding one, a phenomenon referred to as "original antigenic sin." It was of interest, therefore, to investigate the antibody response that develops following exposure to the malaria vaccine candidate homologue Plasmodium yoetii MSP1 19 in mice that had previously experienced malaria infection and vice versa. In this study, preexposure of mice to Plasmodium yoelii elicited native anti-MSPl 19 antibody responses, which could be boosted by vaccination with recombinant MSP1 19. Likewise, infection of MSPl 19-primed mice with P. yoelii led to an increase of anti-MSPl 19 antibodies. However, this increase was at the expense of antibodies to parasite determinants other than MSP1 19. This change in the balance of antibody specificities significantly affected the ability of mice to withstand a subsequent infection. These data have particular relevance to the possible outcome of malaria vaccination for those situations where the vaccine response is suboptimal and suggest that suboptimal vaccination may in fact render the ultimate acquisition of natural immunity more difficult. Copyright © 2009, American Society for Microbiology. All Rights Reserved.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleEffect of plasmodium yoelii exposure on vaccination with the 19-kilodalton carboxyl terminus of merozoite surface protein 1 and vice versa and implications for the application of a human malaria vaccineen_US
Appears in Collections:Scopus 2006-2010

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.