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Title: Does artesunate prolong the electrocardiograph QT interval in patients with severe malaria?
Authors: Richard J. Maude
Katherine Plewes
M. Abul Faiz
Josh Hanson
Prakaykaew Charunwatthana
Sue J. Lee
Joel Tärning
Emran Bin Yunus
M. Gofranul Hoque
Mahatab Uddin Hasan
Amir Hossain
Niklas Lindegardh
Nicholas P.J. Day
Nicholas J. White
Arjen M. Dondorp
Mahidol University
Dhaka Medical College
Chittagong Medical College Hospital
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2009
Citation: American Journal of Tropical Medicine and Hygiene. Vol.80, No.1 (2009), 126-132
Abstract: Several antimalarials can cause significant prolongation of the electrocardiograph QT interval, which can be associated with an increased risk of potentially lethal ventricular arrhythmias. High doses of artemether and artemotil have been associated with QT prolongation in dogs, raising the possibility of a class effect with the artemisinin derivatives. Serial electrocardiograms were recorded, and QTc interval was calculated before and after administration of artesunate by intravenous injection in patients with severe falciparum malaria in Bangladesh. Of 21 adult patients with severe malaria enrolled, 8 (38%) died. The mean QTc interval was unaffected by bolus intravenous artesunate (2.4 mg/kg). In two patients, the QTc interval exceeded 0.5 seconds, but in both cases, an alternative explanation was plausible. No effect was observed on the JTc or PR interval, QRS width, blood pressure, or heart rate. Intravenous artesunate does not have significant cardiovascular effects in patients with severe falciparum malaria. Copyright © 2009 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2006-2010

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