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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/27774
Title: Nonlinear spatiotemporal analysis and modeling of signal transduction pathways involving G protein coupled receptors
Authors: Chontita Rattanakul
Titiwat Sungkaworn
Yongwimon Lenbury
Meechoke Chudoung
Varanuj Chatsudthipong
Wannapong Triampo
Boriboon Novaprateep
Mahidol University
Keywords: Mathematics
Issue Date: 30-Sep-2009
Citation: International Journal of Mathematical Models and Methods in Applied Sciences. Vol.3, No.3 (2009), 219-229
Abstract: Cell behavior and communication are regulated by a complex network of intracellular and extracellular signal transduction pathways. In this paper, a model of signaling process involving G proteins is analyzed. The model incorporates reaction-diffusion mechanisms involving reactants that interact with each other on the cellular membrane surface and its proximity. The ligand-receptor complexes and the inhibiting agents in the process may diffuse over the cell membrane, and the signal transduction is mediated by the membrane bound G protein leading to biochemical intra-cellular reaction and the production of the second messenger or other desired functional responses. Weakly nonlinear stability analysis is carried out in order to investigate the dynamic and steady-state properties of the model. Turing-type patterns are shown to robustly form under conditions on the system parameters which characterize the formation of stationary symmetry breaking structures; stripes and hexagonal arrays of spots or nets. Some recent experimental studies are then mentioned in support of our theoretical predictions.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349428790&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/27774
ISSN: 19980140
Appears in Collections:Scopus 2006-2010

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