Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorChontita Rattanakulen_US
dc.contributor.authorTitiwat Sungkawornen_US
dc.contributor.authorYongwimon Lenburyen_US
dc.contributor.authorMeechoke Chudoungen_US
dc.contributor.authorVaranuj Chatsudthipongen_US
dc.contributor.authorWannapong Triampoen_US
dc.contributor.authorBoriboon Novaprateepen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationInternational Journal of Mathematical Models and Methods in Applied Sciences. Vol.3, No.3 (2009), 219-229en_US
dc.description.abstractCell behavior and communication are regulated by a complex network of intracellular and extracellular signal transduction pathways. In this paper, a model of signaling process involving G proteins is analyzed. The model incorporates reaction-diffusion mechanisms involving reactants that interact with each other on the cellular membrane surface and its proximity. The ligand-receptor complexes and the inhibiting agents in the process may diffuse over the cell membrane, and the signal transduction is mediated by the membrane bound G protein leading to biochemical intra-cellular reaction and the production of the second messenger or other desired functional responses. Weakly nonlinear stability analysis is carried out in order to investigate the dynamic and steady-state properties of the model. Turing-type patterns are shown to robustly form under conditions on the system parameters which characterize the formation of stationary symmetry breaking structures; stripes and hexagonal arrays of spots or nets. Some recent experimental studies are then mentioned in support of our theoretical predictions.en_US
dc.rightsMahidol Universityen_US
dc.titleNonlinear spatiotemporal analysis and modeling of signal transduction pathways involving G protein coupled receptorsen_US
Appears in Collections:Scopus 2006-2010

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.