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dc.contributor.authorChontita Rattanakulen_US
dc.contributor.authorTitiwat Sungkawornen_US
dc.contributor.authorYongwimon Lenburyen_US
dc.contributor.authorMeechoke Chudoungen_US
dc.contributor.authorVaranuj Chatsudthipongen_US
dc.contributor.authorWannapong Triampoen_US
dc.contributor.authorBoriboon Novaprateepen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-09-13T06:47:38Z-
dc.date.available2018-09-13T06:47:38Z-
dc.date.issued2009-09-30en_US
dc.identifier.citationInternational Journal of Mathematical Models and Methods in Applied Sciences. Vol.3, No.3 (2009), 219-229en_US
dc.identifier.issn19980140en_US
dc.identifier.other2-s2.0-70349428790en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349428790&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/27774-
dc.description.abstractCell behavior and communication are regulated by a complex network of intracellular and extracellular signal transduction pathways. In this paper, a model of signaling process involving G proteins is analyzed. The model incorporates reaction-diffusion mechanisms involving reactants that interact with each other on the cellular membrane surface and its proximity. The ligand-receptor complexes and the inhibiting agents in the process may diffuse over the cell membrane, and the signal transduction is mediated by the membrane bound G protein leading to biochemical intra-cellular reaction and the production of the second messenger or other desired functional responses. Weakly nonlinear stability analysis is carried out in order to investigate the dynamic and steady-state properties of the model. Turing-type patterns are shown to robustly form under conditions on the system parameters which characterize the formation of stationary symmetry breaking structures; stripes and hexagonal arrays of spots or nets. Some recent experimental studies are then mentioned in support of our theoretical predictions.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349428790&origin=inwarden_US
dc.subjectMathematicsen_US
dc.titleNonlinear spatiotemporal analysis and modeling of signal transduction pathways involving G protein coupled receptorsen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
Appears in Collections:Scopus 2006-2010

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