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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/27789
Title: Positively selected G6PD-mahidol mutation reduces Plasmodium vivax density in Southeast Asians
Authors: Chalisa Louicharoen
Etienne Patin
Richard Paul
Issarang Nuchprayoon
Bhee Witoonpanich
Chayanon Peerapittayamongkol
Isabelle Casademont
Thanyachai Sura
Nan M. Laird
Pratap Singhasivanon
Lluis Quintana-Murci
Anavaj Sakuntabhai
Institut Pasteur, Paris
Chulalongkorn University
CNRS Centre National de la Recherche Scientifique
Mahidol University
Harvard School of Public Health
Inserm
Keywords: Medicine;Multidisciplinary
Issue Date: 11-Dec-2009
Citation: Science. Vol.326, No.5959 (2009), 1546-1549
Abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency - the most common known enzymopathy - is associated with neonatal jaundice and hemolytic anemia usually after exposure to certain infections, foods, or medications. Although G6PD-deficient alleles appear to confer a protective effect against malaria, the link with clinical protection from Plasmodium infection remains unclear. We investigated the effect of a common G6PD deficiency variant in Southeast Asia-the G6PD-Mahidol487A variant - on human survival related to vivax and falciparum malaria. Our results show that strong and recent positive selection has targeted the Mahidol variant over the past 1500 years. We found that the G6PD-Mahidol487A variant reduces vivax, but not falciparum, parasite density in humans, which indicates that Plasmodium vivax has been a driving force behind the strong selective advantage conferred by this mutation.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=72149127949&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/27789
ISSN: 10959203
00368075
Appears in Collections:Scopus 2006-2010

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