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Title: Newer developments in the treatment of Gram-positive infections
Authors: Pornpan Koomanachai
Jared L. Crandon
David P. Nicolau
Hartford Hospital
Mahidol University
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Dec-2009
Citation: Expert Opinion on Pharmacotherapy. Vol.10, No.17 (2009), 2829-2843
Abstract: Gram-positive organisms are continually a major cause of infection. These organisms are ever-evolving and exhibit resistance to nearly all available agents. Historically, vancomycin was crowned the drug of choice for many of these organisms including methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, and penicillin-resistant Enterococcus spp. Many of these organisms have exhibited reduced susceptibility or frank resistance to vancomycin which has resulted in treatment failure. For this reason, new strategies in treating Gram-positive infections are a hot topic. There are two general approaches to waging this war: i) development of new antimicrobial agents; and ii) reinvigorating old antibiotics that still retain appreciable activity against Gram-positives. We review both antibiotic groupings with a focus on S. aureus, S. pneumoniae and Enterococcus spp. © 2009 Informa UK Ltd.
ISSN: 14656566
Appears in Collections:Scopus 2006-2010

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