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Title: The surgical outcome of preoperative chemoradiation therapy for ultra low rectal cancer
Authors: Wiroon Boonnuch
Varut Lohsiriwat
Thawatchai Akaraviputh
Vitoon Chinswangwatanakul
Darin Lohsiriwat
Mahidol University
Keywords: Medicine
Issue Date: 1-Nov-2009
Citation: Journal of the Medical Association of Thailand. Vol.92, No.11 (2009), 1423-1427
Abstract: Objective: To evaluate the surgical outcome of preoperative long-course chemoradiation therapy (PCRT) in patients with ultra low rectal cancer. Material and Method: Medical records of patients with rectal adenocarcinoma located within the length of 5 cm from the anal verge, who underwent elective oncological resection between 2003 and 2006 at Siriraj Hospital, were reviewed. PCRT was performed in some patients based on tumor characteristics and surgeon's decision. Rate of sphincter preservation and other surgical outcomes were assessed. Results: Ninety-three patients with an average age of 60 years were studied. Twenty-seven (29%) received PCRT. There was no difference in demographic data and location of the tumor between PCRT and non-PCRT group. Patients with PCRT had a smaller size of tumor (2.6 vs. 5.0 cm, p < 0.001) and better tumor staging (p < 0.001). Complete pathological response was found in four patients with PCRT (15%). However, there was no significant difference in SPP rate between PCRT and non-PCRT group (37% vs. 36%, p = 0.95). Other surgical outcomes between the two groups were also not different. Conclusion: PCRT did not increase rate of sphincter preservation in patients with low rectal cancer.
ISSN: 01252208
Appears in Collections:Scopus 2006-2010

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