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dc.contributor.authorWalther H. Wernsdorferen_US
dc.contributor.authorSabariah Ismailen_US
dc.contributor.authorKit Lam Chanen_US
dc.contributor.authorKanungnit Congpuongen_US
dc.contributor.authorGunther Wernsdorferen_US
dc.contributor.otherMedizinische Universitat Wienen_US
dc.contributor.otherUniversiti Sains Malaysiaen_US
dc.contributor.otherThailand Ministry of Public Healthen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-09-13T06:53:38Z-
dc.date.available2018-09-13T06:53:38Z-
dc.date.issued2009-10-01en_US
dc.identifier.citationWiener Klinische Wochenschrift. Vol.121, No.SUPPL. 3 (2009), 23-26en_US
dc.identifier.issn00435325en_US
dc.identifier.other2-s2.0-73449104239en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=73449104239&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/27914-
dc.description.abstractThe habitats of Eurycoma longifolia Jack, a slender tree, are jungles in Malaysia and Indonesia. It belongs to the family Simaroubaceae and is a source of quassinoids with anabolic, antimalarial and cytostatic activity. In this study, conducted during 2008 in Mae Sot, Thailand, a standardized extract of E. longifolia containing three major quassinoids, eurycomanone (1), 13,21-dihydroeurycomanone (2) and 13α(21)-epoxyeurycomanone (3) was evaluated for antiplasmodial activity against Plasmodium falciparum and its activity has been compared with that of artemisinin, using 38 fresh parasite isolates and assessment of inhibition of schizont maturation. The IC50, IC90and IC99values for artemisinin were 4.30, 45.48 and 310.97 μg/l, and those for the root extract from E. longifolia 14.72, 139.65 and 874.15 μg/l respectively. The GMCOC for artemisinin was 337.81 μg/l, and for the plant extract it was 807.41 μg/l. The log-concentration probit regressions were parallel. The inhibitory activity of the E. longifolia extract was higher than that expected from the three quassinoids isolated from the plant, suggesting synergism between the quassinoids or the presence of other unidentified compounds. © 2009 Springer-Verlag.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=73449104239&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleActivity of Eurycoma longifolia root extract against Plasmodium falciparum in vitroen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1007/s00508-009-1230-7en_US
Appears in Collections:Scopus 2006-2010

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