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dc.contributor.authorJan Maresen_US
dc.contributor.authorVisith Thongboonkerden_US
dc.contributor.authorZdenek Tumaen_US
dc.contributor.authorJiri Moravecen_US
dc.contributor.authorMartin Matejovicen_US
dc.contributor.otherFakultni nemocnice Plzenen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherCharles Universityen_US
dc.date.accessioned2018-09-13T06:57:19Z-
dc.date.available2018-09-13T06:57:19Z-
dc.date.issued2009-08-01en_US
dc.identifier.citationKidney International. Vol.76, No.4 (2009), 404-413en_US
dc.identifier.issn15231755en_US
dc.identifier.issn00852538en_US
dc.identifier.other2-s2.0-68249092090en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=68249092090&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/27992-
dc.description.abstractDialyser bioincompatibility is an important factor contributing to complications of hemodialysis with well known systemic consequences. Here we studied the local processes that occur on dialysis membranes by eluting proteins adsorbed to the polysulfone dialyser membranes of 5 patients after 3 consecutive routine maintenance hemodialysis sessions. At the end of each procedure, a plasma sample was also collected. These eluates and their accompanying plasma samples were separated by 2-dimensional gel electrophoresis; all proteins that were present in all patients were analyzed by tandem mass spectrometry; and a ratio of the relative spot intensity of the eluate to plasma was calculated. Of 153 proteins detected, 84 were found in all patients, 57 of which were successfully identified by mass spectrometry as 38 components of 23 unique proteins. In 10 spots the relative eluate intensity differed significantly from that in the plasma, implying preferential adsorption. These proteins included ficolin-2, clusterin, complement C3c fragment, and apolipoprotein A1. Our finding of a selective binding of ficolin-2 to polysulfone membranes suggests a possible role of the lectin complement pathway in blood-dialyser interactions. © 2009 International Society of Nephrology.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=68249092090&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleSpecific adsorption of some complement activation proteins to polysulfone dialysis membranes during hemodialysisen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1038/ki.2009.138en_US
Appears in Collections:Scopus 2006-2010

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