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Title: Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common
Authors: White, Nicholas J
Guo Qiao, Li
Qi, Gao
Luzzatto, Lucio
Mahidol University. Faculty of Tropical Medicine. Tropical Medicine Research Unit
Keywords: Plasmodium falciparum;gametocytocide;primaquine;G6PD;Open Access article
Issue Date: 2012
Citation: Malaria Journal. Vol.11, (2012), 418
Abstract: In areas of low malaria transmission, it is currently recommended that a single dose of primaquine (0.75 mg base/kg; 45 mg adult dose) be added to artemisinin combination treatment (ACT) in acute falciparum malaria to block malaria transmission. Review of studies of transmission-blocking activity based on the infectivity of patients or volunteers to anopheline mosquitoes, and of haemolytic toxicity in glucose 6-dehydrogenase (G6PD) deficient subjects, suggests that a lower primaquine dose (0.25 mg base/kg) would be safer and equally effective. This lower dose could be deployed together with ACTs without G6PD testing wherever use of a specific gametocytocide is indicated.
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