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dc.contributor.authorWhite, Nicholas Jen_US
dc.contributor.authorGuo Qiao, Lien_US
dc.contributor.authorQi, Gaoen_US
dc.contributor.authorLuzzatto, Lucioen_US
dc.contributor.otherMahidol University. Faculty of Tropical Medicine. Tropical Medicine Research Uniten_US
dc.date.accessioned2017-09-11T07:29:35Z-
dc.date.available2017-09-11T07:29:35Z-
dc.date.created2017-09-11-
dc.date.issued2012-
dc.identifier.citationMalaria Journal. Vol.11, (2012), 418-
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/2803-
dc.description.abstractIn areas of low malaria transmission, it is currently recommended that a single dose of primaquine (0.75 mg base/kg; 45 mg adult dose) be added to artemisinin combination treatment (ACT) in acute falciparum malaria to block malaria transmission. Review of studies of transmission-blocking activity based on the infectivity of patients or volunteers to anopheline mosquitoes, and of haemolytic toxicity in glucose 6-dehydrogenase (G6PD) deficient subjects, suggests that a lower primaquine dose (0.25 mg base/kg) would be safer and equally effective. This lower dose could be deployed together with ACTs without G6PD testing wherever use of a specific gametocytocide is indicated.en_US
dc.language.isoenen_US
dc.rightsMahidol Universityen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectgametocytocideen_US
dc.subjectprimaquineen_US
dc.subjectG6PDen_US
dc.subjectOpen Access article-
dc.titleRationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is commonen_US
dc.typeResearch Articleen_US
dc.rights.holderBioMed Centralen_US
dc.identifier.urlhttp://www.malariajournal.com/content/11/1/418-
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