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Title: Evidence suggesting a genetic contribution to kidney stone in northeastern Thai population
Authors: Suchai Sritippayawan
Sombat Borvornpadungkitti
Atchara Paemanee
Chagkrapan Predanon
Wattanachai Susaengrat
Duangporn Chuawattana
Nunghathai Sawasdee
Sirintra Nakjang
Suttikarn Pongtepaditep
Choochai Nettuwakul
Nanyawan Rungroj
Somkiat Vasuvattakul
Prida Malasit
Pa Thai Yenchitsomanus
Mahidol University
Khon Kaen Regional Hospital
Thailand National Center for Genetic Engineering and Biotechnology
Keywords: Medicine
Issue Date: 1-Jun-2009
Citation: Urological Research. Vol.37, No.3 (2009), 141-146
Abstract: Genetic factor may play a role in the pathogenesis of kidney stone that is found in the northeastern (NE) Thai population. Herein, we report initial evidence suggesting genetic contribution to the disease in this population. We examined 1,034 subjects including 135 patients with kidney stone, 551 family members, and 348 villagers by radiography of kidney-ureter-bladder (KUB) and other methods, and also analyzed stones removed by surgical operations. One hundred and sixteen of 551 family members (21.05%) and 23 of the 348 villagers (6.61%) were affected with kidney stone. The relative risk (λR) of the disease among family members was 3.18. Calcium stones (whewellite, dahllite, and weddellite) were observed in about 88% of stones analyzed. Our data indicate familial aggregation of kidney stone in this population supporting that genetic factor should play some role in its pathogenesis. Genetic and genomic studies will be conducted to identify the genes associated with the disease. © 2009 Springer-Verlag.
ISSN: 03005623
Appears in Collections:Scopus 2006-2010

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