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Title: Plaque reduction neutralization antibody test does not accurately predict protection against dengue infection in Ratchaburi cohort, Thailand
Authors: Chukiat Sirivichayakul
Arunee Sabchareon
Kriengsak Limkittikul
Sutee Yoksan
Mahidol University. Faculty of Tropical Medicine. Department of Tropical Pediatrics
Keywords: Dengue;Plaque reduction neutralization test;Neutralizing antibody;Open Access article
Issue Date: 2014
Citation: Virology Journal. Vol.11, (2014), 48
Abstract: Background: The plaque reduction neutralization test (PRNT) is currently the best and most widely accepted approach to measuring virus-neutralizing and protective antibodies to dengue virus, and in assessing the immunogenicity of a dengue vaccine. However, the correlation between presence of dengue-neutralizing antibody and protection from infection is not absolute. Findings: In a cohort study in Ratchaburi Province, Thailand, 48 subjects with serologically confirmed symptomatic dengue infection were tested for pre-existing dengue neutralizing antibody using PRNT. Nine subjects had quite high pre-existing PRNT50 titers (titer >90) to subsequent infecting dengue serotypes, but still had symptomatic infections. Conclusion: This report provides evidence that PRNT may not be a good test for predicting protection against subsequent dengue infection.
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