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Title: Risk and prognostic significance of tuberculosis in patients from The TREAT Asia HIV Observational Database
Authors: Jialun Zhou
Julian Elliott
Patrick C.K. Li
Poh Lian Lim
Sasisopin Kiertiburanakul
Nagalingeswaran Kumarasamy
Tuti Parwati Merati
Sanjay Pujari
Yi Ming A. Chen
Praphan Phanuphak
Saphonn Vonthanak
Thira Sirisanthana
Somnuek Sungkanuparph
Christopher K.C. Lee
Adeeba Kamarulzaman
Shinichi Oka
Fujie Zhang
Goa Tau
Rossana Ditangco
Kirby Institute
Queen Elizabeth Hospital Hong Kong
Tan Tock Seng Hospital
Mahidol University
YR Gaitonde Centre for AIDS Research and Education
Universitas Udayana
Institute of Infectious Diseases
National Yang-Ming University Taiwan
The HIV Netherlands Australia Thailand Research Collaboration
National Center for HIV/AIDS
Research Institute for Health Sciences
Hospital Sungai Buloh
University of Malaya
National Center for Global Health and Medicine
Beijing Ditan Hospital
Port Moresby General Hospital
Keywords: Medicine
Issue Date: 21-Apr-2009
Citation: BMC Infectious Diseases. Vol.9, (2009)
Abstract: Background: To assess the risk and the prognostic significance of tuberculosis (TB) diagnosis in patients from The TREAT Asia HIV Observational Database, a multi-centre prospective cohort of HIV-infected patients receiving HIV care in the Asia-Pacific region. Methods: The risk of TB diagnosis after recruitment was assessed in patients with prospective follow-up. TB diagnosis was fitted as a time-dependent variable in assessing overall survival. Results: At baseline, 22% of patients were diagnosed with TB. TB incidence was 1.98 per 100 person-years during follow up, with predictors including younger age, lower recent CD4 count, duration of antiretroviral treatment, and living in high TB burden countries. Among 3279 patients during 6968 person-years, 142 died (2.04 per 100 person-years). Compared to patients with CDC category A or B illness only, mortality was marginally higher in patients with single Non-TB AIDS defining illness (ADI), or TB only (adjusted HR 1.35, p = 0.173) and highest in patients with multiple non-TB AIDS or both TB and other ADI (adjusted HR 2.21, p < 0.001). Conclusion: The risk of TB diagnosis was associated with increasing immunodeficiency and partly reduced by antiretroviral treatment. The prognosis of developing TB appeared to be similar to that following a diagnosis of other non-TB ADI. © 2009 Zhou et al; licensee BioMed Central Ltd.
ISSN: 14712334
Appears in Collections:Scopus 2006-2010

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