Simple jQuery Dropdowns
Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/28115
Title: Differential prevalence of plasmodium infections and cryptic plasmodium knowlesi malaria in humans in Thailand
Authors: Chaturong Putaporntip
Thongchai Hongsrimuang
Sunee Seethamchai
Teerayot Kobasa
Kriengsak Limkittikul
Liwang Cui
Somchai Jongwutiwes
Molecular Biology of Malaria and Opportunistic Parasites Research Unit
Mahidol University
Naresuan University
Thailand Ministry of Public Health
Pennsylvania State University
Chulalongkorn University
Keywords: Medicine
Issue Date: 15-Apr-2009
Citation: Journal of Infectious Diseases. Vol.199, No.8 (2009), 1143-1150
Abstract: Background. A case of human infection with Plasmodium knowlesi has been recently discovered in Thailand. To investigate the prevalence of this malaria species, a molecular-based survey was performed. Methods. Blood samples from 1874 patients were tested for Plasmodium species by microscopy and nested polymerase chain reaction. P. knowlesi was characterized by sequencing the merozoite surface protein 1 gene (msp-1). Results. Of all Plasmodium species identified, P. falciparum, P. vivax, P. malariae, P. ovale, and P. knowlesi contributed 43.52%, 68.08%, 1.37%, 1.03%, and 0.57%, respectively. Mixed-species infections were more common in northwestern and southwestern regions bordering Myanmar (23%-24%) than in eastern and southern areas (3%- 5%). In northwestern and southwestern regions, mixed-species infections had a significantly higher prevalence in dry than in rainy seasons (P < .001). P. knowlesi was found in 10 patients, mostly from southern and southwestern areas-9 were coinfected with either P. falciparum or P. vivax. Most of the P. knowlesi Thai isolates were more closely related to isolates from macaques than to isolates from Sarawak patients. The msp-1 sequences of isolates from the same area of endemicity differed and possessed novel sequences, indicating genetic polymorphism in P. knowlesi infecting humans. Conclusions. This survey highlights the widespread distribution of P. knowlesi in Thailand, albeit at low prevalence and mostly occurring as cryptic infections. © 2009 by the Infectious Diseases Society of America.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=65649123388&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/28115
ISSN: 00221899
Appears in Collections:Scopus 2006-2010

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.