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Title: Causes of death in HIV-infected persons who have tuberculosis, Thailand
Authors: Kevin P. Cain
Thanomsak Anekthananon
Channawong Burapat
Somsak Akksilp
Wiroj Mankhatitham
Chawin Srinak
Sriprapa Nateniyom
Wanchai Sattayawuthipong
Theerawit Tasaneeyapan
Jay K. Varma
Centers for Disease Control and Prevention
Mahidol University
Thailand Ministry of Public Health
Office of Disease Prevention and Control 7
Bamrasnaradura Infectious Disease Institute
Bangkok Metropolitan Administration
Phuket Provincial Public Health Office
Keywords: Medicine
Issue Date: 1-Feb-2009
Citation: Emerging Infectious Diseases. Vol.15, No.2 (2009), 258-264
Abstract: Up to 50% of persons with HIV and a diagnosis of tuberculosis (TB) in Thailand die during TB treatment. In a prospective observational study, a team of physicians ascribed the cause of death after reviewing verbal autopsies (interviews of family members about events preceding death), laboratory data, and medical records. Of 849 HIV- infected TB patients enrolled, 142 (17%) died. The cause of death was TB for 38 (27%), including 6 with multidrug- resistant TB and 20 with disseminated TB; an HIV-associ- ated condition other than TB for 50 (35%); and a condition unrelated to TB or HIV for 22 (15%). Twenty-three patients (16%) were judged not to have had TB at all. Death from all causes except those unrelated to TB or HIV was less common in persons receiving antiretroviral therapy (ART). In addition to increasing the use of ART, death rates may be reduced through expanded use of modern TB diagnostic techniques.
ISSN: 10806059
Appears in Collections:Scopus 2006-2010

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