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Title: Three novel single nucleotide polymorphisms of UGT1A9 in a Thai population
Authors: Porntipa Korprasertthaworn
Wandee Udomuksorn
Krongtong Yoovathaworn
Mahidol University
Prince of Songkla University
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2009
Citation: Drug Metabolism and Pharmacokinetics. Vol.24, No.5 (2009), 482-485
Abstract: The human UDP-glucuronosyltransferase, UGT1A9, catalyzes glucuronidation of various endobiotics and xenobiotics. In this study, we sequenced the promoter and exon 1 regions of the UGT1A9 gene in 93 Thai individuals and identified 7 genetic polymorphisms. The allele frequencies of all 3 novel single nucleotide polymorphisms (SNPs): 454A>G and 455A>C (N152A) and 760C>T (R254X) were 0.005. The other 4 known polymorphisms, -688A>C, 440T>C, 331C>T -118A(T)10AT (UGT1A9*1b), were identified and found to have frequencies of 0.124, 0.978, 0.968 and 0.532, respectively.
ISSN: 18800920
Appears in Collections:Scopus 2006-2010

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