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Title: Transcriptional regulation of iNOS and COX-2 by a novel compound from Curcuma comosa in lipopolysaccharide-induced microglial activation
Authors: Anusorn Thampithak
Yamaratee Jaisin
Benjawan Meesarapee
Sukumal Chongthammakun
Pawinee Piyachaturawat
Piyarat Govitrapong
Porntip Supavilai
Yupin Sanvarinda
Mahidol University
The Institute of Science and Technology for Research and Development, Mahidol University
Keywords: Neuroscience
Issue Date: 22-Sep-2009
Citation: Neuroscience Letters. Vol.462, No.2 (2009), 171-175
Abstract: Overproduction of pro-inflammatory mediators resulting from chronic activation of microglia has been implicated in many neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease. In this study, we investigated the effects of (3R) 1,7-diphenyl-(4E,6E)-4,6-heptadien-3-ol, or compound 049 on the production of pro-inflammatory mediators in lipopolysaccharide (LPS)-treated microglia. Compound 049 is a pure compound fractionated from the hexane extract of Curcuma comosa, an indigenous plant of Thailand traditionally used as an anti-inflammatory agent for the treatment of uterine inflammation. It was found that pretreatment of the highly aggressively proliferating immortalized (HAPI), rat microglial cell line, with compound 049, at the concentrations of 0.1, 0.5 and 1 μM significantly decreased LPS-induced NO and PGE2production in a concentration-dependent manner. Parallel to the decreases in NO and PGE2production was a reduction in the expression of inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) as measured by mRNA and protein levels. These results indicate that compound 049 possesses an anti-inflammatory activity and may have a therapeutic potential for the treatment of neurodegenerative diseases related to microglial activation. © 2009 Elsevier Ireland Ltd. All rights reserved.
ISSN: 03043940
Appears in Collections:Scopus 2006-2010

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