Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: The modulatory effect of substance P on rat pineal norepinephrine release and melatonin secretion
Authors: Sujira Mukda
Morten Møller
Manuchair Ebadi
Piyarat Govitrapong
The Institute of Science and Technology for Research and Development, Mahidol University
Panum Institute
School of Medicine
Mahidol University
Keywords: Neuroscience
Issue Date: 15-Sep-2009
Citation: Neuroscience Letters. Vol.461, No.3 (2009), 258-261
Abstract: Secretion of melatonin by the mammalian pineal gland is primarily regulated by the release of norepinephrine (NE) from sympathetic nerve terminals that originate from the superior cervical ganglia. Peptidergic nerves that originate in the perikarya located in the sensory trigeminal ganglia also innervate the pineal gland. Some of these peptidergic nerve fibers contain substance P. Previously, we have characterized neurokinin 1 type substance P receptors in the pineal gland. However, the function of this receptor in the pineal gland remains unclear. Here, we examined the modulatory effect of substance P on rat pineal NE transmission. We show that at the presynaptic level, substance P stimulates the KCl-induced [3H]NE release from the pineal nerve ending. However, we found that substance P did not affect the basal levels of either arylalkylamine-N-acetyltransferase (AANAT) activity or melatonin secretion in rat pineal organ cultures. However, in the presence of NE, substance P inhibited the NE-induced increase in AANAT activity and melatonin secretion. This is the first time that a function for substance P in the mammalian pineal gland has been demonstrated. © 2009 Elsevier Ireland Ltd. All rights reserved.
ISSN: 03043940
Appears in Collections:Scopus 2006-2010

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.