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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/28334
Title: Effects of oxygen-containing terpenes as skin permeation enhancers on the lipoidal pathways of human epidermal membrane
Authors: Doungdaw Chantasart
Thaned Pongjanyakul
William I. Higuchi
S. Kevin Li
Mahidol University
Khon Kaen University
University of Utah
University of Cincinnati
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2009
Citation: Journal of Pharmaceutical Sciences. Vol.98, No.10 (2009), 3617-3632
Abstract: The present study investigated the effects of oxygen-containing terpenes as skin permeation enhancers on the lipoidal pathways of human epidermal membrane (HEM). The enhancement (EHEM) effects of menthol, thymol, carvacrol, menthone, and cineole on the transport of a probe permeant, corticosterone, across HEM were determined. It was found that the enhancer potencies of menthol, thymol, carvacrol, and menthone were essentially the same and higher than that of cineole based on their aqueous concentration in the diffusion cell chamber at EHEM=4. Thymol and carvacrol also had the same EHEM=10 concentration further supporting that they had the same enhancer potency based on the aqueous concentration. The uptake amounts of terpene into the HEM stratum corneum (SC) intercellular lipid under the same conditions indicate that the intrinsic potencies of the studied terpenes are the same based on their concentration in the SC and similar to those of n-alkanol and n-alkylphenyl alcohol. Moreover, they are all better enhancers compared to branched-chain alkanol. The approximately same uptake enhancement of β-estradiol induced by the studied terpenes and alcohols at EHEMconditions into the SC intercellular lipids suggests that the mechanism of enhancement action for the terpenes and those of alcohols are essentially the same. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67649638118&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/28334
ISSN: 15206017
00223549
Appears in Collections:Scopus 2006-2010

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