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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/28428
Title: A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity
Authors: Supaluk Prachayasittikul
Ratchanok Pingaew
Apilak Worachartcheewan
Somsak Ruchirawat
Virapong Prachayasittikul
Srinakharinwirot University
Mahidol University
Chulabhorn Research Institute
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Dec-2010
Citation: EXCLI Journal. Vol.9, (2010), 102-107
Abstract: Bioactivities of thiotetrahydropyridines were previously described. Herein, a novel bioactive sulfoxide analog; N-acetyl-2-(1-adamantylsulfoxo)-3-acetoxy-4-phenyl-6-hydroxy-1,2,3,6-tet rahydropyridine (3) from the deoxydative substitution of 4-phenylpyridine 1-oxide is reported. Its structure was elucidated using spectral data including 2D-NMR, MS, IR and UV. The sulfoxide 3 exhibited antibacterial activity against Moraxella catarrhalis and Streptococcus pyogenes with minimum inhibitory concentration of 128 and 256 μg/mL, respectively.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79151486711&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/28428
ISSN: 16112156
Appears in Collections:Scopus 2006-2010

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