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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/28471
Title: Heritability of the human infectious reservoir of malaria parasites
Authors: Yaye Ramatoulaye Lawaly
Anavaj kuntabhai
Laurence Marrama
Lassana Konate
Waraphon Phimpraphi
Cheikh Sokhna
Adama Tall
Fatoumata Diène Sarr
Chayanon Peerapittayamongkol
Chalisa Louicharoen
Bradley S. Schneider
Anaïs Levescot
Arthur Talman
Isabelle Casademont
Didier Menard
Jean François Trape
Christophe Rogier
Jaranit Kaewkunwal
Thanyachai Sura
Issarang Nuchprayoon
Frederic Ariey
Laurence Baril
Pratap Singhasivanon
Odile Mercereau-Puijalon
Rick Paul
Institut Pasteur de Dakar
Institut Pasteur, Paris
Universite Cheikh Anta Diop
Mahidol University
Institut de Recherche pour le Developpement Dakar
Institut Pasteur du Cambodge
IMTSSA Institut de Medecine Tropicale du Service de Sante des Armees
Chulalongkorn University
CNRS Centre National de la Recherche Scientifique
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 12-Aug-2010
Citation: PLoS ONE. Vol.5, No.6 (2010)
Abstract: Background: Studies on human genetic factors associated with malaria have hitherto concentrated on their role in susceptibility to and protection from disease. In contrast, virtually no attention has been paid to the role of human genetics in eliciting the production of parasite transmission stages, the gametocytes, and thus enhancing the spread of disease. Methods and Findings: We analysed four longitudinal family-based cohort studies from Senegal and Thailand followed for 2-8 years and evaluated the relative impact of the human genetic and non-genetic factors on gametocyte production in infections of Plasmodium falciparum or P. vivax. Prevalence and density of gametocyte carriage were evaluated in asymptomatic and symptomatic infections by examination of Giemsa-stained blood smears and/or RT-PCR (for falciparum in one site). A significant human genetic contribution was found to be associated with gametocyte prevalence in asymptomatic P. falciparum infections. By contrast, there was no heritability associated with the production of gametocytes for P. falciparum or P. vivax symptomatic infections. Sickle cell mutation, HbS, was associated with increased gametocyte prevalence but its contribution was small. Conclusions: The existence of a significant human genetic contribution to gametocyte prevalence in asymptomatic infections suggests that candidate gene and genome wide association approaches may be usefully applied to explore the underlying human genetics. Prospective epidemiological studies will provide an opportunity to generate novel and perhaps more epidemiologically pertinent gametocyte data with which similar analyses can be performed and the role of human genetics in parasite transmission ascertained. © Lawaly et al.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77956209235&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/28471
ISSN: 19326203
Appears in Collections:Scopus 2006-2010

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