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Title: Genome sequence of the necrotrophic plant pathogen Pythium ultimum reveals original pathogenicity mechanisms and effector repertoire
Authors: C. André Lévesque
Henk Brouwer
Liliana Cano
John P. Hamilton
Carson Holt
Edgar Huitema
Sylvain Raffaele
Gregg P. Robideau
Marco Thines
Joe Win
Marcelo M. Zerillo
Gordon W. Beakes
Jeffrey L. Boore
Dana Busam
Bernard Dumas
Steve Ferriera
Susan I. Fuerstenberg
Claire M.M. Gachon
Elodie Gaulin
Francine Govers
Laura Grenville-Briggs
Neil Horner
Jessica Hostetler
Rays H.Y. Jiang
Justin Johnson
Theerapong Krajaejun
Haining Lin
Harold J.G. Meijer
Barry Moore
Paul Morris
Vipaporn Phuntmart
Daniela Puiu
Jyoti Shetty
Jason E. Stajich
Sucheta Tripathy
Stephan Wawra
Pieter van West
Brett R. Whitty
Pedro M. Coutinho
Bernard Henrissat
Frank Martin
Paul D. Thomas
Brett M. Tyler
Ronald P. De Vries
Sophien Kamoun
Mark Yandell
Ned Tisserat
C. Robin Buell
Agriculture et Agroalimentaire Canada
Carleton University
CBS Fungal Biodiversity Center CBS - KNAW
The Sainsbury Laboratory
Michigan State University
University of Utah Health
Biodiversity and Climate Research Centre
Goethe-Universitat Frankfurt am Main
Colorado State University
Newcastle University, United Kingdom
Genome Project Solutions
J. Craig Venter Institute
Universite de Toulouse
The Scottish Association for Marine Science
Wageningen University and Research Centre
Centre for Biosystems Genomics, Wageningen
University of Aberdeen School of Medicine
Broad Institute
Mahidol University
Bowling Green State University
University of California, Riverside
Biocomplexity Institute of Virginia Tech
Universite de Provence Aix-Marseille 1
USDA Agricultural Research Service, Washington DC
SRI International
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 13-Jul-2010
Citation: Genome Biology. Vol.11, No.7 (2010)
Abstract: Background: Pythium ultimum is a ubiquitous oomycete plant pathogen responsible for a variety of diseases on a broad range of crop and ornamental species.Results: The P. ultimum genome (42.8 Mb) encodes 15,290 genes and has extensive sequence similarity and synteny with related Phytophthora species, including the potato blight pathogen Phytophthora infestans. Whole transcriptome sequencing revealed expression of 86% of genes, with detectable differential expression of suites of genes under abiotic stress and in the presence of a host. The predicted proteome includes a large repertoire of proteins involved in plant pathogen interactions, although, surprisingly, the P. ultimum genome does not encode any classical RXLR effectors and relatively few Crinkler genes in comparison to related phytopathogenic oomycetes. A lower number of enzymes involved in carbohydrate metabolism were present compared to Phytophthora species, with the notable absence of cutinases, suggesting a significant difference in virulence mechanisms between P. ultimum and more host-specific oomycete species. Although we observed a high degree of orthology with Phytophthora genomes, there were novel features of the P. ultimum proteome, including an expansion of genes involved in proteolysis and genes unique to Pythium. We identified a small gene family of cadherins, proteins involved in cell adhesion, the first report of these in a genome outside the metazoans.Conclusions: Access to the P. ultimum genome has revealed not only core pathogenic mechanisms within the oomycetes but also lineage-specific genes associated with the alternative virulence and lifestyles found within the pythiaceous lineages compared to the Peronosporaceae. © 2010 Lévesque et al.; licensee BioMed Central Ltd.
ISSN: 1474760X
Appears in Collections:Scopus 2006-2010

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